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丁先玲 (Ding, Shian-ling, Ph.D.)

  專任教授

  護理健康學院院長視光科主任

  台北市內湖區康寧路三段75巷137號

  Tel: 886-2-26321181# 585

  Fax: 886-2-23649857

  E-mail: slding@ukn.edu.tw

 

教職及學歷

教授證書(教字第○一九九四六號)

副教授證書(副字第○三六三八一號)

助理教授證書(助理字第一三○三八號)

講師證書(講字第二八八四三號)

中華民國眼科醫學會繼續教育種子教師(證明書編號第106029號)

行政院衛生署(2年)應用流行病學調查人員(證書字第016號)

行政院衛生署預防醫學研究所流行病學訓練班講師

生命科學研究所-(92)博字第018

公共衛生(含流行病學)研究所-碩士(76)碩字第004495

護理學士(70)大字第14801

英國長照實務增能研習(Canterbury Christ Church University)

考試院衛生行政人員特考通過

護理師(護理字第6690號)

經歷

康寧醫護暨管理專科學校務主任

康寧醫護暨管理專科學校教師發展中心主任

康寧醫護暨管理專科學校護理科主任

國防醫學院醫學研究部研究人員

國防醫學院講師

三軍總醫院癌症流行病學研究室講師

三軍總醫院國防醫學院雜誌編輯委員

三軍總醫院精神科護理師

三軍總醫院重症加護病房護理師

研究

   1. 國科會研究計畫

名 稱

擔任工作

執行時間

核定機構

經 費(元)

台灣地區婦女衰老基因WRN 多型性與乳癌易感受性的相關分析-病例對照研究(2年)

Breast Cancer Risk Associated with Genotypic Polymorphism of the Premature Aging Gene, WRN:A Case-Control Study on Cancer Susceptibility

主持人

95/08/01 ~ 96/07/31

國科會

1,952,000

台灣地區婦女之α-雌激素受體基因(ESR1)多位點單一核苷酸單套基因多型性與乳癌易感受性的相關分析-病例對照研究(2年)

Haplotype Analysis of Single Nucleotide Polymorphisms in Estrogen Receptor AlphaESR1Gene for Breast Cancer Risk: A Large Case-Control Study on Cancer Susceptibility.

主持人

96/08/01 ~ 98/07/31

國科會

1,940,000

探討FBXW7/CDC4抑癌基因多型性在乳癌組織中特定表達模式對病理特徵及其臨床預後之相關(3年)

Breast cancer risk associated with the genetic polymorphism of putative tumor suppression gene, FBXW7/CDC4, in relation to its expression profiles: emphasis on clinicopathological features and prognostic outcomes

主持人

98/08/01 ~101/07/31

國科會

3,000,000

    2. 研院獎勵國內學人短期來院訪問研究計畫

早衰基因WRN遺傳變異與乳癌易感受性的相關-病例對照研究(6個月)

Genetic Variation in the Premature Aging Gene, WRN: A Case-Control Study on Breast Cancer Susceptibility

主持人

94/07/01 ~ 94/12/31

中研院

120,000

    3. 國際學術會議 (論文發表)

    ─ American Association for Cancer Research (AACR) Annual Meeting 2007 in San Diego, CA, USA

    ─ American Association for Cancer Research (AACR) Annual Meeting 2008 in San Diego, CA, USA

    ─ Kyoto Breast Cancer Consensus Conference International Convention 2009 in Kyoto, Japan

    ─ American Association for Cancer Research (AACR) Annual Meeting 2010 in Washington, DC, USA

    ─ American Association for Cancer Research (AACR) Annual Meeting 2012,  in Chicago, Illinois, USA

    4. 國內學術會議

    ─ 台灣流行病學學會/SNP-based Association Study Work Shops

   台北醫學院教研大樓1F, 2004-9-11 (專題: Linkage Disequilibrium and Haplotype Analysis

    ─ 第五屆生命科學研究所論文研討會 Aspire learning & recreation center (Title: Molecular mechanism underlying early-onset breast cancer), June-23-2004.

    5. 國際性學術刊物邀稿 Review for Clinical Interventions in Aging期刊(Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes. Clinical Interventions in Aging 2008; 3(3): 1–14.) 

    6. 國際性SCI學術刊物審稿 Molecular MedicineImpact Factor3.349

    7. 國內學術刊物審稿 護理雜誌

學位論文

生命科學博士論文

Molecular Mechanism Underlying Early-onset Breast Cancer(<35歲女性早發性乳癌的分子機制)

公共衛生碩士論文

Risk Factors of Preterm Delivery of Tri-Service General Hospital-A Case-Control Study(早產危險因子)

個人著作

  1. Lin WY, et al. (Ding SL is listed as the 193rd author among 221 authors) Identification and characterization of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk. Hum Mol Genet  2015;24:285-298. (SCI; Impact Factor =8.058).
  2. Michailidou K, et al., (Ding SL is listed as the 206th author among 224 authors ) Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat Genet 2013;45:353-61. (SCI; Impact Factor = 35.209).
  3. Cheng CW, Liu YF, Yu JC, Wang HW, Ding SL, Hsiung CN, Hsu HM, Shieh JC, Wu PE, Shen CY. Prognostic significance of cyclin D1, β-catenin, and MTA1 in patients with invasive ductal carcinoma of the breast. Ann Surg Oncol 2012;19(13):4129-39. (SCI; Impact Factor = 4.12).
  4. Cheng CW, Wang HW, Chang CW, Chu HW, Chen CY, Yu JC, Chao JI, Liu HF, Ding SL, Shen CY. MicroRNA-30a inhibits cell migration and invasion by downregulating vimentin expression and is a potential prognostic marker in breast cancer. Breast Cancer Res Treat 2012;134(3):1081-93. (SCI; Impact Factor = 4.469).
  5. Figueroa JD, et al., (Ding SL is listed as the 133rd author among 147 authors). Associations of common variants at 1p11.2 and 14q24.1 (RAD51L1) with breast cancer risk and heterogeneity by tumor subtype: findings from the Breast Cancer Association Consortium. Hum Mol Genet 2011;20:4693-706. (SCI; Impact Factor =8.058)
  6. Ding SL, Yu JC, Chen ST, Hsu GC, Hsu HM, Ho JY, Lin YH, Chang CC, Fann CS, Cheng CW, Wu PE, Shen CY. Diverse associations between ESR1 polymorphism and breast cancer development and progression. Clin Cancer Res 2010;16(13): 3473-3484. (SCI; Impact Factor =6.747
  7. Yu JC, Hsiung CN, Hsu HM, Bao BY, Chen ST, Hsu GC, Chou WC, Hu LY, Ding SL, Cheng CW, Wu PE, Shen CY. Genetic variation in the genome-wide predicted estrogen response element-related sequences is associated with breast cancer development. Breast Cancer Research 2011;13(1):R13 (SCI; Impact Factor =5.33)
  8. Hsu MS, Yu JC, Wang HW, Chen ST, Hsiung CN, Ding SL, Wu PE, Shen CY, Cheng CW. Synergistic Effects of Polymorphisms in DNA Repair Genes and Endogenous Estrogen Exposure on Female Breast Cancer Risk. Ann Surg Oncol 2010;17(3):760-771.(SCI; Impact Factor =4.130
  9. Ding SL, Yu JC, Chen ST, Hsu GC, Kuo SJ, Lin YH, Wu PE, and Shen CY. Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility. Carcinogenesis 2009; 30(1):43-49. (SCI; Impact Factor =5.406
  10. Yu JC, Ding SL, Chang CH, Kuo SH, Chen ST, Hsu GC, Hsu HM, Hou MF, Jung LY, Cheng CW, Wu PE, Shen CY. Genetic susceptibility to the development and progression of breast cancer associated with polymorphism of cell-cycle and ubiquitin ligase genes. Carcinogenesis 2009; 30(9):1562-1570. (SCI; Impact Factor =5.406)
  11. Ding SL, Yu JC and Shen CY. Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes. Clinical Interventions in Aging 2008; 3(3): 1–14.
  12. Ding SL, Yu JC and Shen CY. Mutational Screening of BRCA1 Gene on 93 Early-onset Breast Cancer Patients in Taiwan. Academic Journal of Kang-Ning 2008;10:1-23.
  13. Chou WC, Wang HC, Wong FH, Ding SL, Wu PE, Shief SY, Shen CY. Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair. EMBO J, 2008;27:3140-3150.(SCI; Impact Factor =8.662
  14. Bau DT, Mau YC, Ding SL, Wu PE, Shen CY. DNA Double-Strand-Break Repair Capacity and Risk of Breast Cancer. Carcinogenesis 2007; 28(8):1726-1730. (SCI; Impact Factor =5.108
  15. Ding SL, Yu JC, Chen ST, Hsu GC, Shen CY. Genetic Variation in the Premature Aging Gene, WRN: a Case-Control Study on Breast Cancer Susceptibility. Cancer Epidemiology, Biomarkers and Prevention 2007; 16 (2):263-269. (SCI; Impact Factor =4.642
  16. Ding SL, Sheu LF, Yu JC, Yang TL, Chen BF, Leu FJ and Shen CY. Abnormality of the DNA double-strand-break checkpoint/repair genes, ATM, BRCA1 and TP53, in breast cancer is related to tumour grade. British Journal of Cancer 2004; 90: 1995-2001. (SCI; Impact Factor = 4.635
  17. Ding SL, Sheu LF, Yu JC, Yang TL, Chen BF, Leu FJ and Shen CY.  Expression of estrogen receptor-α and Ki67 in relation to different pathological and molecular features in early-onset infiltrating ductal carcinoma. J BioMed Sci 2004; 11(6): 911-919. (SCI; Impact Factor =2.024
  18. Chen A, Sheu LF, Ding SL, Shaio MF, Lee WH. Antiidotype directly interferes with the glomerular localization of IgA immune complexes. Nephron 1998; 78:234-243. (SCI; Impact Factor =13.26
  19. Ding SL, Yen LL. Behavioral factors related to motorcyclist’s head injuries, with emphasis on high-risk group. Public Health 1996; 23:239-246.
  20. Chen A, Chu WY, Sheu LF, Wei CH, Ding SL, Lee WH. Induction of proteinuria by adriamycin, bovine serum albumin or puromycin aminonucleoside in themouse. Nephron 1995; 69:293-300. (SCI; Impact Factor =13.26
  21. Ding SL, Wang JD, Chen KT. Epidemiological analysis of 845 cases of pedestrian traffic injuries. Chin Med J 1994; 53:16-22.
  22. Ding SL, Pai L, Wang JD, Chen KT. Head injuries in traffic accidents with emphasis on the comparisons between motorcycle-helmet users and non users. J Formosan Med Assoc 1994; 93:s42-48.
  23. Ding SL, Pai L, Hsu WL. The premature years of potential life lost and sex differences on main causes of death in Taiwan. J Med Sci 1994; 14:397-404.
  24. Ding SL, Pai L, Hsu WL. Medical Statistics: survival analysis. Medical Digest 1994; 18:406-410.
  25. Chen A, Ding SL, Song YB, Chou WY, Shau MF. Experimental IgA nepheopathy: enhancement of glomerular IgA immune complex deposition in heavy proteinuric state. Lab Invest 1994; 70:639-647.(SCI; Impact Factor =4.405)
  26. Ding SL, Hsu WL. Cancer registration—functions and objectives. Medical Digest 1993; 17:542-545.
  27. Ding SL, Hsu WL. Trend of three leading cause of death in Taiwan. Medical Digest 1993; 16:156-162.
  28. Chen TK, Yao CT, Chen LT, Hwang WS, Ding SL. Surgical treatment of pancreatic adenocarcinoma in Taiwan. Asian J Surgery 1993; 16:289-293. (SCI; Impact Factor =0.52)
  29. Ding SL, Wang JD, Hsu WL. Trend of cumulative mortality rate and years of potential life lost on accidents, malignant neoplasm and cerebrovascular attacks in Taiwan(1971~1990). J Natl Public Health Assoc 1993; 12: 84-91.
  30. Ding SL, Wang JD, Chen KT. Estimation of case fatality rate and incidence rate of traffic injury in Taiwan—analysis of 4,329 victims at a medical center. J Formosan Med Assoc 1993; 9:s76-81.
  31. Chen A, Ding SL, Chou WY, Shau MF. Formation of precipitated complexes with charge–distinct model antigens: establishment of experimental glomerulonephropathy with the lack of antibody involvement. Lab Invest 1992; 67:175-185. (SCI; Impact Factor =4.405)
  32. Ger PL, Shen CY, Ko WS, Chiang HH, Pai L, Ding SL, Kao SJ. Physicians’ attitude toward cancer. J Med Sci 1992; 13:31-40.
  33. Ding SL: An epidemiological study of traffic injuries in Taiwan. Epidemiology Bulletin 1992; 8:255-260.
  34. Ding SL, Yin CS, Ger LP et al. A clinical study on 268 patients with cervical carcinoma. Chin Med J 1991; 48: 439-444.
  35. Ding SL, Ko WS, Hwang WS, et al. Non-Hodgkin’s lymphoma in adults: a clinical-pathologic study of 169 cases. J Formosan Med Assoc 1990; 89:1017-1022.
  36. Ger PL, Ding SL, Shen CY, et al. Survival of lung cancer patients of different histologic types. J Formosan Med Assoc 1990; 89:407-412.
  37. Chen LM, Ko WS, Wang CC, Ding SL, Wu KL, Hware WS. Mulyiple primary cancers in digestive system. J Chinese Oncol Soc 1990; 6:153-161.
  38. Ding SL, Ger PL, Kao SJ, Shen CY. Small cell lung cancer: survival analysis of 96 cases. Chin Med J 1989; 43: 197-204.

 

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